The Ultimate Guide To https://www.ceesdekker.net
The Ultimate Guide To https://www.ceesdekker.net
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2009, discovery of a completely new phenotype for microorganisms in slender nanofluidic slits; and to start with detection of local protein structures along DNA utilizing reliable-condition nanopores
Human Rad51 filaments on double- and single-stranded DNA: correlating frequent and irregular kinds with recombination perform.
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
Considering that 2000, Dekker has shifted the main target of his do the job towards biophysics the place he studies the Qualities of solitary biomolecules and cells using the applications of nanotechnology. This modification of subject was pushed by his fascination for the impressive performing of Organic molecular structures, along with because of the long-term viewpoint a large number of attention-grabbing discoveries can be envisioned Within this area.[5] Existing lines of analysis in his biophysics group are inside the regions of:[6]
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Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-movie voltammetry
Because 2000 he moved to one-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with micro organism on chip, even though his greatest desire is from the path of realizing artificial cells.
2000, discovery that nanotubes can carry remarkable substantial present densities; solved the controversial issue of electronic transportation through DNA molecules by measurements of insulating conduct at The only molecule amount; and demonstration of an AFM strategy for one-molecule manipulation of nanotubes
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Bulk-surface coupling identifies the mechanistic link amongst Min-protein styles in vivo and in vitro
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2006, to start with demonstration of molecular sorting within a lab over a chip applying biomotors; discovery of nanobubbles in sound-point out nanopores; and to start with estimate of electrokinetic Vitality conversion in a very nanofluidic channel
As an example, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a really intricate technique and thus difficult to analyze in the cell, so we use biomimetics. We reconstruct holes after which you can insert particular person factors of the nucleopore elaborate to review transportation by cees dekker way of it at the single-molecule stage.’
It absolutely was a really appealing time, throughout which I acquired loads of assistance from Delft University of Technological know-how, exactly where I used to be a professor at enough time, And that i started numerous collaborations with molecular biologists. That aided me master a great deal.’